In this presentation, Melissa Naiman, PhD, EMT-B shares the fundamentals of Monocyte Distribution Width (MDW) and explains the clinical utility of incorporating the MDW biomarker as part of the complete blood count with differential (CBC-diff) early in ED screening to aid in identifying risk of severe infection and sepsis in your emergency department.
00:18- What is MDW
0:37 - MDW Basics
0:48 - Challenges in Sepsis Screening
1:44 - Activation of monocytes by pathogens
2:07 - MDW as a risk stratification tool
2:44 - Interpreting MDW results
2:57 - What does an elevated MDW result mean?
3:26 - MDW Clinical Evidence
3:29 - Increased MDW values correlate with infection
3:09 - US Study
4:02 -EU Study
4:17 -Asia Study
4:24 - Johns Hopkins
4:33 - MDW Clinical Utility
4:43 - Predictive value of MDW was enhanced when combined with WBC results
5:36 -Predictive value of MDW with or without WBC results was not enhanced when combined with PCT or CRP
6:02 - MDW provides an additional, objective data point early in the patient journey
6:40 - Learn more about MDW Protocol Example in ED at www.beckmancoulter.com/sepsis
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